The Canadian entrepreneur has always pushed the boundaries of gene editing, once attempting to turn horses into unicorns. Now she is set on modifying human embryos – something her controversial ex-husband was jailed for doing

On a Friday evening in late April, Cathy Tie, the Canadian serial entrepreneur and self-styled “Biotech Barbie”, is centre stage at New York City’s famous Carnegie Hall, performing Saint-Saens’ Piano Concerto No 2 on a gleaming Steinway grand piano, accompanied by an orchestra. Her floor-length pink tulle gown shimmers with gold sequins; her dark hair cascades in waves over her caped shoulders. The music is passionate, but Tie’s expression is impassive. Her eyes dart between the piano keys and the sheet music in a flurry of concentration, but the rest of her face is totally still. She isn’t lost in the music; she’s focused on the job.

After the last notes ring out, Tie stands up and breaks into a tight smile and a brief bow before walking off stage, only to immediately return to receive the slightly awkward Happy Birthday sung by everyone in the orchestra and auditorium. This is Tie’s 30th birthday party. She has hired Carnegie Hall to mark the occasion. And, as I discover at the cocktail afterparty, most of the people invited to this performance – including me – have either only just met Tie or don’t know her at all.

As flights and hotels sell out and prices soar, supporters go to great lengths to see Gunners face Paris Saint-Germain

Since Arsenal’s euphoric Premier League win last week, it has been a never-ending party in much of north London (apart from in Tottenham, although they had their own cause for celebration). And with Arsenal poised to play in the Uefa Champions League final on Saturday, Gooner fever is about to spread to the continent. So it was not surprising that in Stansted’s departure lounge, about 30 miles north-east of central London, the team’s iconic red-and-white shirts were an unmissable sight on Friday morning.

Most Gunners – or Gooners, as they are colloquially known – were preparing to embark on (mostly indirect) journeys to Budapest, where Arsenal will face Paris Saint-Germain. “We’ll get there by train, plane and automobiles,” said Darren Cornish. The 53-year-old IT manager from Hemel Hampstead was not exaggerating. Arsenal fans the Guardian spoke to plan on trekking to the Hungarian capital via overnight buses and trains from surrounding countries after flights to Budapest spiked following their Premier League victory.

Some Iranians hoped foreign intervention would unseat the regime but instead the US-Israel war has damaged livelihoods and strengthened those in power

As Donald Trump swung this week between threats of new military action against Iran and predictions that a lasting ceasefire deal was imminent, many Iranians were left exhausted and gripped by uncertainty.

Despite the partial lifting of an internet shutdown that began when the war started on 28 February, fears of worsening repression at home have also fuelled pessimism about the future among some of those to whom the Guardian spoke.

He insists he is so right but gets so much badly wrong, not least the absurdity that the UK should have joined Donald Trump in the quagmire that is Iran

Give the man credit. Tony Blair has achieved a goal that even a week ago seemed impossible, and which he scarcely managed in office: he has brought the Labour party together in sweet, harmonious unity. Thanks to him, Andy Burnham, Wes Streeting and the man they hope to replace, Keir Starmer, are singing in unison, joined in a chorus of denunciation – of one T Blair.

Give the triple election-winner further credit. This is a political professional who still knows how to command the news cycle. Cannily timing the release of his nearly 6,000-word essay on the future of Britain, and the failings of Labour, to coincide with the parliamentary recess, he secured for himself massive coverage across all platforms over several days.

Jonathan Freedland is a Guardian columnist

Do you have an opinion on the issues raised in this article? If you would like to submit a response of up to 300 words by email to be considered for publication in our letters section, please click here.

The Netherlands has the lowest rate of young people not in education, employment or training in the EU

A shock government-backed report this week warned of the danger of a “lost generation” of young people in Britain, as the number of 16- to 24-year-olds not in education, employment or training (Neets) rose to more than 1 million.

According to official UK statistics, roughly 13.5% of young people are not in work or college. Among 18- to 24-year-olds the share rises to 15.8% – nearly one in six.

Mikel Arteta must find the balance between newfound freedom and tried-and-tested solidity against Luis Enrique’s attacking machine

Welcome to Budapest: city of stew, city of pavement squares, city of men in cotton smocks offering brisk muscular relaxation in geothermally heated cubicles. Eleven days on from the profound emotional release of winning the Premier League title it seems fitting Arsenal will approach their season’s endgame in a city that is basically perfect for a restorative summer city break.

Saturday afternoon at the Puskas Arena already looks like a twin-track event for Mikel Arteta’s team, an occasion that changes shape according to the angle from which you see it. On one hand, victory against Paris Saint-Germain in the Champions League final would represent the greatest day in Arsenal’s history. On the other, this is an occasion that feels strangely light, fun, celebratory, a free-hit kind of final.

Trial suggests patients with a low test score could be treated with hormone therapy alone with near-identical outcomes

• ‘Like Christmas’: woman’s relief after test finds she can skip chemotherapy

Millions of women with breast cancer could be spared chemotherapy with a groundbreaking genomic test, according to the results of a trial that could transform healthcare guidelines worldwide.

Treatment for breast cancer, the world’s most prevalent form of the disease, involves surgery to remove tumours. Chemotherapy is then usually recommended when doctors believe there is a risk the disease will return.

Pentagon chief also tells Singapore defence summit of ‘alarm’ at China’s military buildup but says US does not seek ‘needless confrontation’

The US warned on Saturday it was “more than capable” of resuming war with Iran after President Donald Trump said any peace deal must adhere to his red lines, including Tehran never being able to develop nuclear weapons.

The White House had signalled Trump was close to a decision on an initial deal on Friday after weeks of mixed signals in tenuous negotiations, though Tehran denied there was a final agreement on ending the Middle East conflict that has jolted the global economy.

Soho Society, funded by Westminster council, is ferociously opposing all new proposals, venue owners say

A society of residents funded by the council could “destroy Soho’s reputation on the international stage” as London’s entertainment district by ferociously objecting to all new bar and restaurant licences, operators in the area have said.

The Soho Society, a group of residents established in 1972 aimed at “preserving the character of Soho”, voted in its AGM on Thursday for a new licensing mandate, meaning it will challenge all new applications for bars and restaurants in the area, including renewals of existing licences. It will also object to any venue that wishes to open beyond “core hours”, which Westminster council decrees end at 11pm.

People with coeliac disease say inflation and shrinking ranges are making food staples unaffordable

Gluten-free versions of everyday staples such as bread and biscuits are becoming a luxury, with shoppers complaining that a “decent” small loaf now costs nearly £4.

Consumers have always paid a premium for these specialist foods, making any price increases a source of concern, particularly for people who follow a gluten-free diet for medical reasons.